Place the pork roast in a large oval 8 quart slow cooker. Pour the vinegar, liquid smoke, and 1/4 cup water in the bottom of the crock.
Mix the brown sugar and Cajun seasoning together. Rub it all over the pork roast, then pour the leftovers in the bottom of the crock.
Cover the slow cooker. Cook on high for 7-8 hours, or on low for 12+ hours. Once the meat is fork-tender and falling apart, use two forks to shred the pork roast right in the juices. Mix well to coat.
Video
Notes
Serve with southern sides, or on sandwiches, nachos, and tacos!